HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0038023 - signaling receptor activity GO:0043235 - receptor complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1114 Hs			1 2471
+	Hs
		338310 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		980386 NTRK2_HUMAN (590-1018): 1.26e-124: 403: 30.74		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		607947 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		980385 NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		434183 RET_HUMAN (1-1114): 0: 1295: 100.00		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		729266 VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		434229 RET_HUMAN (1-1114): 0: 1295: 100.00		NT2NA_HUMAN (34-171): 1.94e-14: 77: 38.57
+	Hs
		434309 RET_HUMAN (1-1114): 0: 1295: 100.00		NOTC3_HUMAN (1931-2465): 6.29e-11: 70.7: 16.82
+	Hs
		507971 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		507954 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01
+	Hs
		338353 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		338292 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01
+	Hs
		384666 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01
+	Hs
		1021409 NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		257545 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		ANR17_HUMAN (1801-2469): 1.06e-69: 264: 17.34
+	Hs
		507831 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ANK1_HUMAN (1936-2374): 4.06e-52: 205: 13.23
+	Hs
		338533 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		EYS_HUMAN (1-331): 2.94e-48: 193: 30.81
+	Hs
		338035 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		FBN2_HUMAN (474-1671): 8.72e-37: 155: 16.92
+	Hs
		385709 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		NOTC3_HUMAN (1931-2465): 6.29e-11: 70.7: 16.82