HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	32062451, 19914172
Identification Methods	proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 694
+	Mm
		724173 RET_MOUSE (1-1114): 0: 1275: 83.24		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		507983 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		338380 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		383784 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		384791 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		339151 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		384030 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		385735 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		338819 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOC10_HUMAN (6-571): 2.68e-119: 395: 14.59
+	Hs
		508062 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		338561 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		508203 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		338998 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		338764 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		CNKR2_HUMAN (7-393): 3.45e-59: 217: 16.63
+	Hs
		385750 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		PKHA6_HUMAN (5-495): 5.54e-58: 214: 13.33
+	Hs
		609340 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		PKHS1_HUMAN (5-310): 1.59e-42: 162: 17.13
+	Hs
		508205 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		339001 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		385546 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		339053 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		PLEK2_HUMAN (3-111): 6.36e-16: 81.7: 28.95