HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: LRRK1 (Q38SD2)
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)
Gene: LRRK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	29513927, 24947832
Identification Methods	pull down, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	COR~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 2015
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		83510 Y1756_ARATH (244-1039): 0: 597: 14.05		Y1571_ARATH (54-688): 1.46e-128: 436: 15.64
+	At
		84201 Y3463_ARATH (227-1037): 0: 567: 14.03		Y2289_ARATH (864-1552): 4.01e-108: 370: 16.27
+	At
		83704 Y5182_ARATH (190-1039): 0: 595: 14.94		Y4361_ARATH (426-1058): 1.33e-88: 317: 13.41
+	At
		84729 F4I065_ARATH (223-1029): 0: 587: 14.88		Y4361_ARATH (426-1058): 1.33e-88: 317: 13.41
+	At
		83729 Y5182_ARATH (190-1039): 0: 595: 14.94		CLV1_ARATH (4-534): 4.24e-85: 304: 16.33
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		85102 F4I065_ARATH (223-1029): 0: 587: 14.88		RGI2_ARATH (412-1019): 6.55e-81: 294: 11.92
+	At
		186987 Y2451_ARATH (249-1028): 0: 564: 12.43		BRI1_ARATH (51-589): 2.45e-86: 312: 14.19
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		83505 Y1756_ARATH (244-1039): 0: 597: 14.05		PSKR2_ARATH (435-963): 7.97e-67: 249: 12.36
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		95392 F4I065_ARATH (223-1029): 0: 587: 14.88		BAME2_ARATH (4-441): 1.56e-67: 251: 16.34
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		95390 F4I065_ARATH (223-1029): 0: 587: 14.88		Y5639_ARATH (4-446): 7.55e-65: 244: 13.13
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		83480 Y1756_ARATH (244-1039): 0: 597: 14.05		BAME1_ARATH (4-381): 4.85e-55: 212: 13.55
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		83707 Y5182_ARATH (190-1039): 0: 595: 14.94		BAME1_ARATH (4-381): 4.85e-55: 212: 13.55
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		95369 F4I065_ARATH (223-1029): 0: 587: 14.88		BAME1_ARATH (4-381): 4.85e-55: 212: 13.55
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		1338140 RLK6_ARATH (249-1031): 0: 595: 14.37		RPK2_ARATH (4-474): 3.71e-45: 181: 13.45
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		95380 F4I065_ARATH (223-1029): 0: 587: 14.88		TDR_ARATH (4-376): 1.57e-46: 185: 10.71
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		95396 F4I065_ARATH (223-1029): 0: 587: 14.88		RPK2_ARATH (4-474): 3.71e-45: 181: 13.45
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		95375 F4I065_ARATH (223-1029): 0: 587: 14.88		MIK2_ARATH (167-371): 4.1e-37: 155: 19.07
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		83483 Y1756_ARATH (244-1039): 0: 597: 14.05		BAME3_ARATH (4-279): 5.82e-22: 106: 8.33
+	At
		83709 Y5182_ARATH (190-1039): 0: 595: 14.94		BAME3_ARATH (4-279): 5.82e-22: 106: 8.33
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		249743 Y3463_ARATH (227-1037): 0: 567: 14.03		BAME3_ARATH (4-279): 5.82e-22: 106: 8.33