HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: DOK6 (Q6PKX4)
Docking protein 6 (Downstream of tyrosine kinase 6)
Gene: DOK6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15286081
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 331
+	Hs
		434248 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK4_HUMAN (1-316): 7.87e-122: 354: 63.50
+	Hs
		434299 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK5_HUMAN (1-307): 1.22e-117: 343: 70.13
+	Hs
		434273 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK1_HUMAN (6-313): 1.36e-81: 257: 20.06
+	Hs
		235038 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK2_HUMAN (6-329): 2.94e-81: 254: 21.05
+	Hs
		434249 RET_HUMAN (1-1114): 0: 1295: 100.00		FRS2_HUMAN (127-321): 9.61e-39: 145: 20.00
+	Hs
		338574 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK6_HUMAN (1-331): 5.98e-138: 396: 100.00
+	Hs
		338739 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK4_HUMAN (1-316): 7.87e-122: 354: 63.50
+	Hs
		338036 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		IRS1_HUMAN (2-329): 4.83e-80: 266: 18.58
+	Hs
		338891 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK1_HUMAN (6-313): 1.36e-81: 257: 20.06
+	Hs
		235032 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK2_HUMAN (6-329): 2.94e-81: 254: 21.05
+	Mm
		250953 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		DOK2_MOUSE (8-329): 6.29e-80: 250: 20.29
+	Hs
		151678 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		IRS4_HUMAN (6-269): 5.75e-65: 224: 19.33
+	Hs
		338618 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK3_HUMAN (9-325): 7.01e-68: 222: 18.55
+	Hs
		601554 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		FRS2_HUMAN (127-321): 9.61e-39: 145: 20.00
+	Hs
		207292 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FRS3_HUMAN (126-321): 1.01e-42: 155: 22.17
+	Mm
		555269 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		FRS2_MOUSE (127-321): 2.83e-39: 146: 20.51
+	Hs
		508122 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FRS2_HUMAN (127-321): 9.61e-39: 145: 20.00
+	Mm
		555270 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		FRS3_MOUSE (126-321): 2.1e-38: 144: 21.26
+	Hs
		609443 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		FRS2_HUMAN (127-321): 9.61e-39: 145: 20.00
+	Hs
		338745 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		FRS2_HUMAN (127-321): 9.61e-39: 145: 20.00