HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	1.00	0.527

Property	Details
Experiments	28213521
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 630
+	Hs
		434141 RET_HUMAN (1-1114): 0: 1295: 100.00		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Hs
		434125 RET_HUMAN (1-1114): 0: 1295: 100.00		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		208976 RET_HUMAN (1-1114): 0: 1295: 100.00		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Mm
		403421 RET_MOUSE (1-1114): 0: 1275: 83.24		SRC_MOUSE (385-628): 1.58e-45: 171: 15.59
+	Hs
		434130 RET_HUMAN (1-1114): 0: 1295: 100.00		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Hs
		434140 RET_HUMAN (1-1114): 0: 1295: 100.00		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Mm
		643062 RET_MOUSE (1-1114): 0: 1275: 83.24		P85A_MOUSE (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		434170 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48
+	Hs
		601467 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Hs
		507872 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Hs
		522773 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		507818 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		433229 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		YES_HUMAN (367-628): 2.22e-43: 165: 16.12
+	Hs
		507835 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PLCG2_HUMAN (269-630): 5.78e-40: 159: 13.88
+	Hs
		208983 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Hs
		507832 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Hs
		601463 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		507870 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		601492 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48
+	Hs
		507939 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48