HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: RAPH1 (Q70E73)
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)
Gene: RAPH1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 1250
+	Hs
		434186 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		434194 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		508074 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		RAPH1_HUMAN (1-1250): 0: 627: 100.00
+	Hs
		338603 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		RAPH1_HUMAN (1-1250): 0: 627: 100.00
+	Hs
		507999 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB14_HUMAN (160-604): 2.08e-146: 455: 25.28
+	Hs
		338431 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		GRB14_HUMAN (160-604): 2.08e-146: 455: 25.28
+	Hs
		383805 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		GRB14_HUMAN (160-604): 2.08e-146: 455: 25.28
+	Hs
		1031667 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		1054054 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		338370 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		383780 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		338432 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		383806 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		GRB7_HUMAN (217-590): 2.91e-120: 385: 23.61
+	Hs
		729650 VGFR2_HUMAN (344-1105): 2.13e-137: 451: 23.91		GRB10_HUMAN (111-591): 4.23e-121: 389: 24.95
+	Hs
		554307 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		MUC1_HUMAN (540-1249): 7.9e-36: 150: 11.97
+	Hs
		337875 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		MUC1_HUMAN (540-1249): 7.9e-36: 150: 11.97
+	Hs
		383583 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		MUC1_HUMAN (540-1249): 7.9e-36: 150: 11.97
+	Hs
		729657 VGFR2_HUMAN (344-1105): 2.13e-137: 451: 23.91		MDC1_HUMAN (718-1249): 2.96e-14: 80.3: 14.37
+	Hs
		257545 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		ANR17_HUMAN (543-1095): 3.34e-14: 80.2: 12.82
+	Hs
		338769 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		TITIN_HUMAN (586-1241): 1.11e-11: 71.9: 13.92