HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: UNC5B (Q8IZJ1)
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1) (p53RDL1)
Gene: UNC5B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 945
+	Hs
		434263 RET_HUMAN (1-1114): 0: 1295: 100.00		LRIG1_HUMAN (11-537): 2.34e-42: 170: 12.78
+	Mm
		724165 RET_MOUSE (1-1114): 0: 1275: 83.24		LRIG1_MOUSE (1-561): 1.23e-43: 174: 12.94
+	Hs
		508096 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		385149 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		608042 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		UNC5B_HUMAN (1-945): 0: 962: 100.00
+	Hs
		306900 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		UNC5C_HUMAN (32-944): 0: 864: 63.75
+	Hs
		338321 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		ZO1_HUMAN (405-656): 2.76e-51: 198: 20.63
+	Hs
		384706 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		ZO1_HUMAN (405-656): 2.76e-51: 198: 20.63
+	Hs
		1070999 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		LRIG1_HUMAN (11-537): 2.34e-42: 170: 12.78
+	Mm
		936212 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		LRIG1_MOUSE (1-561): 1.23e-43: 174: 12.94
+	Hs
		338841 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		LRIG1_HUMAN (11-537): 2.34e-42: 170: 12.78
+	Hs
		383933 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		LRIG1_HUMAN (11-537): 2.34e-42: 170: 12.78
+	Hs
		1070977 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		LRIG3_HUMAN (11-263): 1.61e-38: 157: 19.23
+	Hs
		338583 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		LRIG3_HUMAN (11-263): 1.61e-38: 157: 19.23
+	Hs
		385273 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		PXDN_HUMAN (2-262): 8.33e-41: 165: 17.80
+	Hs
		383860 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		LRIG3_HUMAN (11-263): 1.61e-38: 157: 19.23
+	Hs
		608212 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		ROBO1_HUMAN (2-257): 1.06e-41: 168: 17.16
+	Dr
		1126612 Q5J1R9_DANRE (395-1008): 1.21e-140: 449: 23.69		Q5J1R9_DANRE (2-477): 1.46e-19: 96.6: 10.60
+	Hs
		146743 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		AGRB1_HUMAN (247-372): 3.68e-16: 86: 25.75
+	Mm
		530201 NTRK2_MOUSE (622-1018): 1.6e-122: 397: 31.33		NCAM1_MOUSE (49-293): 9.57e-24: 110: 14.23