HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: ARFG2 (Q8N6H7)
ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289)
Gene: ARFGAP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 521
+	Hs
		434292 RET_HUMAN (1-1114): 0: 1295: 100.00		ARFG3_HUMAN (3-520): 6.07e-131: 392: 53.80
+	Hs
		434250 RET_HUMAN (1-1114): 0: 1295: 100.00		SMAP2_HUMAN (1-396): 1.69e-56: 196: 16.63
+	Hs
		508103 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ARFG2_HUMAN (1-521): 3.38e-168: 487: 100.00
+	Hs
		169187 MUSK_HUMAN (396-1018): 1.21e-135: 434: 25.28		ARFG2_HUMAN (1-521): 3.38e-168: 487: 100.00
+	Hs
		508212 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ARFG3_HUMAN (3-520): 6.07e-131: 392: 53.80
+	Hs
		1081534 NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19		ARFG2_HUMAN (1-521): 3.38e-168: 487: 100.00
+	Hs
		385560 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		ARFG3_HUMAN (3-520): 6.07e-131: 392: 53.80
+	Hs
		169208 MUSK_HUMAN (396-1018): 1.21e-135: 434: 25.28		ARFG3_HUMAN (3-520): 6.07e-131: 392: 53.80
+	Hs
		608147 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		ARFG3_HUMAN (3-520): 6.07e-131: 392: 53.80
+	Hs
		1081615 NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19		ARFG3_HUMAN (3-520): 6.07e-131: 392: 53.80
+	Hs
		508092 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SMAP1_HUMAN (3-422): 1.15e-61: 211: 16.74
+	Hs
		601555 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		SMAP2_HUMAN (1-396): 1.69e-56: 196: 16.63
+	Hs
		385765 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		GIT1_HUMAN (18-454): 3.31e-66: 229: 13.68
+	Hs
		338675 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SMAP1_HUMAN (3-422): 1.15e-61: 211: 16.74
+	Hs
		508123 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SMAP2_HUMAN (1-396): 1.69e-56: 196: 16.63
+	Hs
		338746 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SMAP2_HUMAN (1-396): 1.69e-56: 196: 16.63
+	Hs
		385239 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		ARAP3_HUMAN (12-247): 1.56e-51: 191: 20.90
+	Hs
		608038 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		SMAP1_HUMAN (3-422): 1.15e-61: 211: 16.74
+	Hs
		608046 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		ARFG1_HUMAN (6-387): 1.44e-62: 211: 21.66
+	Hs
		608061 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		SMAP2_HUMAN (1-396): 1.69e-56: 196: 16.63