HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: DOK4 (Q8TEW6)
Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5)
Gene: DOK4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11470823
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 326
+	Hs
		434219 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK6_HUMAN (1-324): 7.73e-127: 367: 63.89
+	Hs
		434299 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK5_HUMAN (1-308): 7.97e-112: 328: 59.09
+	Hs
		434273 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK1_HUMAN (6-307): 3.1e-88: 274: 21.58
+	Hs
		235038 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK2_HUMAN (6-270): 1.71e-74: 236: 22.62
+	Hs
		434249 RET_HUMAN (1-1114): 0: 1295: 100.00		FRS2_HUMAN (129-323): 3.13e-43: 157: 16.92
+	Hs
		338739 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK4_HUMAN (1-326): 6.82e-138: 395: 100.00
+	Hs
		338574 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK6_HUMAN (1-324): 7.73e-127: 367: 63.89
+	Hs
		338891 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK1_HUMAN (6-307): 3.1e-88: 274: 21.58
+	Hs
		338618 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK3_HUMAN (9-317): 2.23e-75: 241: 18.40
+	Mm
		250953 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		DOK2_MOUSE (8-294): 4.37e-74: 235: 21.64
+	Hs
		235032 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK2_HUMAN (6-270): 1.71e-74: 236: 22.62
+	Hs
		338036 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		IRS1_HUMAN (2-302): 1.34e-63: 219: 18.94
+	Hs
		151678 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		IRS4_HUMAN (6-268): 5.38e-60: 209: 20.92
+	Hs
		207292 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FRS3_HUMAN (126-325): 2.45e-50: 175: 18.32
+	Hs
		601554 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		FRS2_HUMAN (129-323): 3.13e-43: 157: 16.92
+	Mm
		555270 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		FRS3_MOUSE (126-325): 5.72e-47: 166: 15.76
+	Hs
		508122 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FRS2_HUMAN (129-323): 3.13e-43: 157: 16.92
+	Mm
		555269 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		FRS2_MOUSE (129-323): 2.25e-43: 157: 16.41
+	Hs
		609443 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		FRS2_HUMAN (129-323): 3.13e-43: 157: 16.92
+	Hs
		338745 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		FRS2_HUMAN (129-323): 3.13e-43: 157: 16.92