HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: FRS2 (Q8WU20)
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Gene: FRS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	32062451, 11360177
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 508
+	Hs
		434273 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Hs
		235038 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK2_HUMAN (20-293): 4.2e-58: 199: 20.42
+	Hs
		434219 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK6_HUMAN (20-186): 2.83e-53: 184: 25.00
+	Hs
		434248 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK4_HUMAN (20-191): 2.87e-49: 174: 15.03
+	Hs
		434299 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK5_HUMAN (20-177): 8.93e-42: 153: 17.61
+	Hs
		601554 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		508122 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		609443 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Mm
		555269 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		FRS2_MOUSE (1-508): 0: 577: 95.87
+	Hs
		338745 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Hs
		207292 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FRS3_HUMAN (1-508): 8.04e-165: 477: 47.51
+	Hs
		207289 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		FRS3_HUMAN (1-508): 8.04e-165: 477: 47.51
+	Mm
		555270 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		FRS3_MOUSE (1-508): 3.38e-156: 455: 47.41
+	Hs
		338891 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Mm
		250953 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		DOK2_MOUSE (20-293): 2.39e-60: 206: 20.85
+	Hs
		235032 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK2_HUMAN (20-293): 4.2e-58: 199: 20.42
+	Hs
		338574 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK6_HUMAN (20-186): 2.83e-53: 184: 25.00
+	Hs
		338618 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK3_HUMAN (20-286): 7.1e-51: 182: 20.79
+	Hs
		338739 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK4_HUMAN (20-191): 2.87e-49: 174: 15.03
+	Hs
		339065 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK5_HUMAN (20-177): 8.93e-42: 153: 17.61