HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 352
+	Hs
		434170 RET_HUMAN (1-1114): 0: 1295: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		338903 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		508169 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		338425 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Mm
		555266 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		NOSTN_MOUSE (5-349): 2.81e-43: 158: 16.89
+	Hs
		508089 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		NOSTN_HUMAN (5-349): 7.39e-43: 157: 16.08
+	Hs
		338405 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06
+	Rn
		499160 FGFR1_RAT (501-1061): 9.97e-146: 459: 32.44		PLCG1_RAT (44-347): 1.35e-35: 139: 13.86
+	Hs
		601492 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		507939 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Rn
		728442 NTRK1_RAT (376-1018): 1.45e-149: 468: 24.47		GRB2_RAT (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		924589 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		508045 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77
+	Hs
		609244 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		338633 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SH3R1_HUMAN (287-346): 1.48e-12: 70.9: 42.19
+	Rn
		924998 Q9QX70_RAT (426-1113): 1.3e-141: 459: 23.07		GRB2_RAT (295-351): 1.51e-12: 67.8: 43.10
+	Mm
		964559 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Hs
		338251 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		298945 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SRBS2_HUMAN (296-347): 7.69e-10: 62.4: 51.92
+	Hs
		338526 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77