HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: DOK5 (Q9P104)
Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)
Gene: DOK5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15286081, 11470823
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 306
+	Hs
		434219 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK6_HUMAN (1-306): 2.09e-126: 365: 70.13
+	Hs
		434248 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK4_HUMAN (1-298): 9.29e-119: 346: 60.33
+	Hs
		235038 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK2_HUMAN (6-268): 2.63e-76: 240: 22.42
+	Hs
		434273 RET_HUMAN (1-1114): 0: 1295: 100.00		DOK1_HUMAN (6-264): 5.18e-72: 231: 22.59
+	Hs
		434249 RET_HUMAN (1-1114): 0: 1295: 100.00		FRS2_HUMAN (129-263): 9.3e-29: 116: 21.92
+	Hs
		338574 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK6_HUMAN (1-306): 2.09e-126: 365: 70.13
+	Hs
		338739 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK4_HUMAN (1-298): 9.29e-119: 346: 60.33
+	Hs
		235032 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK2_HUMAN (6-268): 2.63e-76: 240: 22.42
+	Mm
		250953 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		DOK2_MOUSE (6-292): 1.38e-75: 238: 20.85
+	Hs
		338891 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK1_HUMAN (6-264): 5.18e-72: 231: 22.59
+	Hs
		338618 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		DOK3_HUMAN (9-267): 4.7e-65: 213: 19.73
+	Hs
		338036 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		IRS1_HUMAN (2-304): 2.19e-61: 212: 19.34
+	Hs
		151678 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		IRS4_HUMAN (6-234): 5.15e-54: 191: 19.47
+	Hs
		207292 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FRS3_HUMAN (126-303): 7.07e-42: 152: 20.79
+	Mm
		555270 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		FRS3_MOUSE (126-303): 4.25e-35: 134: 19.23
+	Hs
		601554 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		FRS2_HUMAN (129-263): 9.3e-29: 116: 21.92
+	Mm
		555269 FGFR1_MOUSE (501-1061): 4.1e-150: 471: 32.61		FRS2_MOUSE (129-263): 9.14e-30: 119: 21.92
+	Hs
		508122 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FRS2_HUMAN (129-263): 9.3e-29: 116: 21.92
+	Hs
		609443 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		FRS2_HUMAN (129-263): 9.3e-29: 116: 21.92
+	Hs
		338745 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		FRS2_HUMAN (129-263): 9.3e-29: 116: 21.92