HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction and 1 others more... GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 1620
+	Hs
		434115 RET_HUMAN (1-1114): 0: 1295: 100.00		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		411274 RET_HUMAN (1-1114): 0: 1295: 100.00		INSR_HUMAN (973-1436): 1.01e-112: 392: 34.25
+	Hs
		434116 RET_HUMAN (1-1114): 0: 1295: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Mm
		724169 RET_MOUSE (1-1114): 0: 1275: 83.24		EPHA5_MOUSE (898-1435): 7.1e-120: 401: 23.15
+	Hs
		384115 RET_HUMAN (1-1114): 0: 1295: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	At
		83598 RLK6_ARATH (249-1031): 0: 595: 14.37		Y1124_ARATH (538-1388): 2.64e-149: 482: 12.76
+	At
		1013324 RLK6_ARATH (249-1031): 0: 595: 14.37		Y2239_ARATH (859-1385): 1.07e-151: 480: 18.28
+	At
		85035 RLK6_ARATH (249-1031): 0: 595: 14.37		Y5457_ARATH (878-1413): 4.87e-149: 472: 18.10
+	At
		95372 F4I065_ARATH (223-1029): 0: 587: 14.88		Y2239_ARATH (859-1385): 1.07e-151: 480: 18.28
+	At
		84996 F4I065_ARATH (223-1029): 0: 587: 14.88		Y5457_ARATH (878-1413): 4.87e-149: 472: 18.10
+	At
		83737 Y5189_ARATH (227-1043): 0: 578: 15.07		Y5457_ARATH (878-1413): 4.87e-149: 472: 18.10
+	At
		83729 Y5182_ARATH (190-1039): 0: 595: 14.94		CLV1_ARATH (675-1012): 9.76e-27: 121: 10.57
+	At
		95392 F4I065_ARATH (223-1029): 0: 587: 14.88		BAME2_ARATH (620-1011): 5.33e-29: 128: 10.15
+	At
		83480 Y1756_ARATH (244-1039): 0: 597: 14.05		BAME1_ARATH (810-1005): 1.54e-16: 87.9: 8.63
+	At
		83707 Y5182_ARATH (190-1039): 0: 595: 14.94		BAME1_ARATH (810-1005): 1.54e-16: 87.9: 8.63
+	At
		95379 F4I065_ARATH (223-1029): 0: 587: 14.88		CEPR1_ARATH (779-1038): 7.92e-19: 95.3: 9.94
+	At
		95390 F4I065_ARATH (223-1029): 0: 587: 14.88		Y5639_ARATH (864-1009): 5.53e-18: 92.9: 10.27
+	At
		95369 F4I065_ARATH (223-1029): 0: 587: 14.88		BAME1_ARATH (810-1005): 1.54e-16: 87.9: 8.63
+	At
		95366 F4I065_ARATH (223-1029): 0: 587: 14.88		RGI4_ARATH (853-1009): 9.68e-14: 78.7: 10.76
+	At
		85102 F4I065_ARATH (223-1029): 0: 587: 14.88		RGI2_ARATH (883-1029): 3.88e-13: 76.8: 10.60