HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: MAN1 (Q9Y2U8)
Inner nuclear membrane protein Man1 (LEM domain-containing protein 3)
Gene: LEMD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1114 Hs			1 911
+	Hs
		508283 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		MAN1_HUMAN (1-911): 0: 1233: 100.00
+	Hs
		385760 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		MAN1_HUMAN (1-911): 0: 1233: 100.00
+	Hs
		338434 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		RBM39_HUMAN (765-890): 4.76e-40: 157: 40.48
+	Hs
		384837 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		RBM39_HUMAN (765-890): 4.76e-40: 157: 40.48
+	Hs
		337960 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		U2AF2_HUMAN (721-874): 1.25e-35: 143: 19.76
+	Hs
		384298 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		U2AF2_HUMAN (721-874): 1.25e-35: 143: 19.76
+	Hs
		385676 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		PUF60_HUMAN (763-873): 2.05e-26: 116: 16.81
+	Hs
		384661 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		U2AF1_HUMAN (757-875): 8.25e-27: 111: 17.14
+	Hs
		212091 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		HTSF1_HUMAN (784-863): 4.04e-20: 98.1: 27.16
+	Hs
		212092 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		HTSF1_HUMAN (784-863): 4.04e-20: 98.1: 27.16