HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: TLN1 (Q9Y490)
Talin-1
Gene: TLN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	35044719, unassigned3713
Identification Methods	unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 2541
+	Hs
		434144 RET_HUMAN (1-1114): 0: 1295: 100.00		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		434145 RET_HUMAN (1-1114): 0: 1295: 100.00		RADI_HUMAN (84-666): 2.05e-80: 280: 13.96
+	Rn
		102482 G3V6K6_RAT (426-1113): 2.32e-141: 458: 23.07		Q99PW9_RAT (1833-2532): 3.1e-141: 473: 18.91
+	Mm
		964572 EGFR_MOUSE (426-1113): 8.96e-142: 459: 22.83		HIP1R_MOUSE (1834-2532): 9.51e-138: 463: 18.93
+	Hs
		299238 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		FARP2_HUMAN (55-1039): 1.12e-121: 415: 12.54
+	Hs
		124356 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		HIP1_HUMAN (1798-2532): 2.31e-117: 402: 20.27
+	Hs
		508287 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FARP1_HUMAN (52-1026): 1.66e-112: 388: 11.82
+	Hs
		507884 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		1070971 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		PTN21_HUMAN (64-973): 1.47e-87: 316: 12.49
+	Hs
		338026 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		MERL_HUMAN (80-638): 1.03e-92: 316: 14.79
+	Hs
		507828 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		337871 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		EZRI_HUMAN (84-666): 2.76e-85: 294: 14.65
+	Hs
		507885 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		RADI_HUMAN (84-666): 2.05e-80: 280: 13.96
+	Hs
		609192 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		RADI_HUMAN (84-666): 2.05e-80: 280: 13.96
+	Hs
		338027 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		RADI_HUMAN (84-666): 2.05e-80: 280: 13.96
+	Hs
		507865 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		MOES_HUMAN (163-404): 1.04e-51: 195: 23.05
+	Hs
		508011 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		PLEC_HUMAN (730-2529): 2.6e-23: 111: 12.52
+	Hs
		601499 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		DYST_HUMAN (422-2075): 3.73e-15: 84.9: 9.63
+	Hs
		508139 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		FERM2_HUMAN (268-416): 1.69e-11: 72: 27.82
+	Hs
		338812 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		FERM2_HUMAN (268-416): 1.69e-11: 72: 27.82