HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32062451
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1114 Hs			1 576
+	Hs
		434196 RET_HUMAN (1-1114): 0: 1295: 100.00		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		601512 FGFR2_HUMAN (501-1065): 3.92e-155: 484: 33.11		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		508002 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		508299 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		339210 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Bt
		94410 F1MWF1_BOVIN (344-1092): 1.48e-137: 450: 23.80		F1N579_BOVIN (1-576): 1.09e-92: 297: 92.91
+	Hs
		729709 VGFR2_HUMAN (344-1105): 2.13e-137: 451: 23.91		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		384843 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		385817 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		607969 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		307502 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Hs
		307492 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Hs
		1057047 NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		307505 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Hs
		729401 VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		203204 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		SYNJ1_HUMAN (246-573): 8.14e-20: 96.3: 14.11
+	Mm
		729409 VGFR3_MOUSE (677-1009): 3.71e-75: 274: 40.43		EPN1_MOUSE (1-576): 1.93e-88: 286: 94.44
+	Hs
		554307 ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43		MUC1_HUMAN (234-571): 1.36e-09: 63.1: 13.82
+	Hs
		337875 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		MUC1_HUMAN (234-571): 1.36e-09: 63.1: 13.82
+	Hs
		383583 ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93		MUC1_HUMAN (234-571): 1.36e-09: 63.1: 13.82