HitPredict

Interactor 1: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.50	0.512

Property	Details
Experiments	20098747
Identification Methods	pull down, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1114 Hs			1 419
+	Hs
		339211 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		508022 FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		338478 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		609511 FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16		SCAPE_HUMAN (25-345): 4.15e-29: 122: 16.91
+	Hs
		385783 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		384210 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		607984 FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		338037 EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		384981 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		MRCKA_HUMAN (32-363): 1.19e-13: 75.1: 15.89
+	Hs
		384384 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		384385 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		385802 NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69		MRCKB_HUMAN (39-356): 2.85e-10: 64.7: 13.60
+	Hs
		729402 VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		738306 FLT3_HUMAN (714-1014): 2.21e-72: 262: 40.00		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00