HitPredict

Interactor 1: TPM2 (P07951)
Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)
Gene: TPM2

Interactor 2: ACTS (P68133)
Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
Gene: ACTA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17194691
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Actin~Tropomyosin
Common GO terms	GO:0005829 - cytosol GO:0005884 - actin filament GO:0006936 - muscle contraction GO:0015629 - actin cytoskeleton
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 377
+	Oc
		886040 TPM1_RABIT (1-284): 3.6e-46: 158: 85.92		ACTS_RABIT (1-377): 0: 605: 100.00
+	Hs
		451234 TPM1_HUMAN (1-284): 4.27e-46: 158: 85.56		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		451236 TPM1_HUMAN (1-284): 4.27e-46: 158: 85.56		ACTC_HUMAN (1-377): 0: 604: 98.94
+	Hs
		451231 TPM1_HUMAN (1-284): 4.27e-46: 158: 85.56		ACTA_HUMAN (1-377): 0: 602: 97.88
+	Hs
		418927 TPM3_HUMAN (1-284): 1.59e-44: 154: 86.27		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		418934 TPM3_HUMAN (1-284): 1.59e-44: 154: 86.27		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Dm
		361163 TPM2_DROME (1-282): 3.59e-36: 132: 47.52		ACT4_DROME (1-377): 0: 622: 91.78
+	Ce
		501477 TPM1_CAEEL (1-282): 6.77e-38: 136: 54.97		ACT4_CAEEL (1-377): 0: 607: 94.16
+	Mm
		892182 TPM4_MOUSE (43-284): 2.21e-35: 129: 66.53		ACTB_MOUSE (5-377): 0: 604: 93.83
+	Dm
		451127 TPM2_DROME (1-282): 3.59e-36: 132: 47.52		ACT6_DROME (1-377): 0: 600: 92.57