HitPredict

Interactor 1: CXB1 (P08034)
Gap junction beta-1 protein (Connexin-32) (Cx32) (GAP junction 28 kDa liver protein)
Gene: GJB1

Interactor 2: CXB2 (P29033)
Gap junction beta-2 protein (Connexin-26) (Cx26)
Gene: GJB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Connexin~Connexin
Common GO terms	GO:0005243 - gap junction channel activity GO:0005922 - connexin complex GO:0007267 - cell-cell signaling GO:0016264 - gap junction assembly GO:0016328 - lateral plasma membrane and 1 others more... GO:1905867 - epididymis development
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 283 Hs			1 226
+	Hs
		661144 CXB2_HUMAN (1-224): 1.7e-123: 353: 64.00		CXB2_HUMAN (1-226): 1.37e-126: 358: 100.00
+	Hs
		661149 CXB2_HUMAN (1-224): 1.7e-123: 353: 64.00		CXA8_HUMAN (2-226): 1.61e-120: 350: 51.46
+	Hs
		661197 CXB2_HUMAN (1-224): 1.7e-123: 353: 64.00		CXA3_HUMAN (2-219): 3.79e-112: 329: 48.26
+	Mm
		657010 CXB6_MOUSE (1-254): 3.98e-130: 371: 58.82		CXB3_MOUSE (1-223): 1.62e-105: 306: 52.00
+	Rn
		435243 CXB2_RAT (1-224): 2.81e-123: 352: 63.11		CXA1_RAT (2-223): 5.91e-105: 309: 43.33
+	Hs
		566966 CXA8_HUMAN (2-277): 2.91e-117: 345: 40.14		CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75
+	Mm
		657011 CXB2_MOUSE (1-224): 2.15e-122: 350: 62.67		CXB3_MOUSE (1-223): 1.62e-105: 306: 52.00
+	Hs
		567354 CXA3_HUMAN (2-233): 8.3e-114: 336: 43.73		CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75
+	Hs
		566949 CXG1_HUMAN (1-263): 2.64e-113: 333: 30.33		CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75
+	Mm
		613301 CXG1_MOUSE (1-263): 2.98e-111: 328: 29.82		CXA1_MOUSE (2-223): 7.11e-105: 309: 43.33
+	Hs
		661148 CXB2_HUMAN (1-224): 1.7e-123: 353: 64.00		CXA5_HUMAN (2-225): 8.14e-95: 282: 43.75
+	Hs
		734430 CXA3_HUMAN (2-233): 8.3e-114: 336: 43.73		CXG1_HUMAN (1-222): 9.87e-100: 296: 32.70
+	Rn
		435207 CXA1_RAT (2-227): 2.82e-108: 320: 42.86		CXA1_RAT (2-223): 5.91e-105: 309: 43.33
+	Hs
		274164 CXA3_HUMAN (2-233): 8.3e-114: 336: 43.73		CXB3_HUMAN (1-224): 1.88e-99: 291: 52.44
+	Mm
		613302 CXA1_MOUSE (2-227): 3.66e-108: 320: 42.86		CXB3_MOUSE (1-223): 1.62e-105: 306: 52.00
+	Hs
		734419 CXG1_HUMAN (1-263): 2.64e-113: 333: 30.33		CXD3_HUMAN (2-224): 1.14e-84: 254: 36.44