HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 245
+	Hs
		435597 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		435604 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		435553 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		435554 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		435594 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		411315 INSR_HUMAN (32-1365): 0: 1219: 56.54		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		411316 INSR_HUMAN (32-1365): 0: 1219: 56.54		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Dm
		448232 INSR_DROME (12-1356): 0: 910: 32.97		1433Z_DROME (1-245): 3.68e-141: 397: 77.14
+	At
		965369 CLV1_ARATH (340-1268): 0: 585: 15.24		14332_ARATH (3-243): 8.65e-144: 404: 61.22
+	Hs
		384604 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		169169 MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		384306 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		384623 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		674386 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		384357 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		674348 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		384358 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		169164 MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		384689 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		384598 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33