HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: CALX (P27824)
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Gene: CANX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 592
+	Hs
		161003 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		411305 INSR_HUMAN (32-1365): 0: 1219: 56.54		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		160999 INSR_HUMAN (32-1365): 0: 1219: 56.54		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Rn
		544766 INSR_RAT (20-1365): 0: 1210: 55.45		CALR_RAT (67-470): 7.8e-147: 431: 37.35
+	Hs
		654090 EPHA3_HUMAN (666-1311): 0: 564: 24.96		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654091 EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654899 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654092 LTK_HUMAN (989-1319): 5.64e-75: 270: 40.11		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		384315 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654101 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		CALX_HUMAN (1-592): 0: 786: 100.00
+	At
		83441 Y1755_ARATH (494-1295): 0: 563: 16.93		CALX2_ARATH (68-554): 4.23e-159: 467: 40.91
+	Hs
		507869 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654370 NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		160995 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		601814 ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		161008 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		161071 NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		161016 ERBB3_HUMAN (15-362): 5.41e-25: 115: 18.88		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		384313 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33
+	Hs
		653493 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33