HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: DNJA1 (P31689)
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
Gene: DNAJA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 397
+	Hs
		243262 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		435729 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		411313 INSR_HUMAN (32-1365): 0: 1219: 56.54		DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00
+	Hs
		243254 INSR_HUMAN (32-1365): 0: 1219: 56.54		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		411469 INSR_HUMAN (32-1365): 0: 1219: 56.54		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		435790 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		411515 INSR_HUMAN (32-1365): 0: 1219: 56.54		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		537779 INSRR_HUMAN (14-1310): 0: 1170: 55.26		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Dm
		448256 INSR_DROME (12-1356): 0: 910: 32.97		Q9VFV9_DROME (1-397): 1.49e-137: 400: 58.77
+	Hs
		384352 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		DNJA1_HUMAN (1-397): 3.98e-171: 485: 100.00
+	Hs
		243669 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		665541 EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		243251 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55
+	Hs
		666634 LTK_HUMAN (989-1319): 5.64e-75: 270: 40.11		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		385330 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93
+	Hs
		384289 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		DNJB1_HUMAN (5-347): 8.67e-117: 345: 32.59
+	Mm
		1142038 MUSK_MOUSE (993-1262): 1.48e-69: 254: 43.31		DNJA3_MOUSE (2-387): 1.71e-113: 341: 25.31
+	Hs
		1354290 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		666658 LTK_HUMAN (989-1319): 5.64e-75: 270: 40.11		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15
+	Hs
		385658 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		DJB11_HUMAN (7-330): 1.64e-46: 164: 36.15