HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36736316, 36931259
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 248
+	Hs
		435597 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		435604 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		435542 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		435553 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		435594 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		411316 INSR_HUMAN (32-1365): 0: 1219: 56.54		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		411315 INSR_HUMAN (32-1365): 0: 1219: 56.54		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Dm
		448232 INSR_DROME (12-1356): 0: 910: 32.97		1433Z_DROME (1-245): 4.71e-99: 290: 66.12
+	At
		965369 CLV1_ARATH (340-1268): 0: 585: 15.24		14332_ARATH (3-248): 2.23e-144: 405: 58.47
+	Hs
		384358 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		169164 MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		384604 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		169169 MUSK_HUMAN (993-1262): 8.25e-69: 251: 42.96		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		384623 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		674386 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		384306 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		384357 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		384598 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		674348 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		384689 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20