HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29559623, 16382134
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, STAT_alpha~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030335 - positive regulation of cell migration GO:0043491 - phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1367 Hs			1 770
+	Hs
		411328 INSR_HUMAN (32-1365): 0: 1219: 56.54		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Rn
		94369 INSR_RAT (20-1365): 0: 1210: 55.45		F1M9D6_RAT (1-749): 0: 935: 51.71
+	Hs
		411341 INSR_HUMAN (32-1365): 0: 1219: 56.54		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		411330 INSR_HUMAN (32-1365): 0: 1219: 56.54		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		776626 EPHA5_HUMAN (666-1275): 2.52e-173: 545: 24.01		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776856 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		849879 EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		384414 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		855286 EPHB4_HUMAN (648-1305): 5.48e-162: 514: 23.20		STAT2_HUMAN (1-728): 0: 786: 38.47
+	Hs
		507894 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		609197 FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		384428 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Mm
		786519 ERBB2_MOUSE (26-308): 1.01e-27: 124: 19.88		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		384522 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		STA5B_HUMAN (1-734): 0: 752: 30.55