HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: ECHA (P40939)
Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]
Gene: HADHA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0044877 - protein-containing complex binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1367 Hs			1 763
+	Rn
		431429 INSR_RAT (20-1365): 0: 1210: 55.45		ECHP_RAT (43-763): 0: 740: 28.69
+	Hs
		778087 EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		778157 EPHA7_HUMAN (656-1342): 1.15e-177: 555: 23.39		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		778086 EPHA5_HUMAN (666-1275): 2.52e-173: 545: 24.01		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		778331 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		384420 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		674351 UFO_HUMAN (790-1271): 9.27e-68: 249: 32.10		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		507896 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		778161 NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		609198 FGFR3_HUMAN (972-1266): 2.05e-63: 234: 38.44		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		665557 EPHB2_HUMAN (496-674): 6.85e-19: 95.5: 17.88		ECHA_HUMAN (1-763): 0: 942: 100.00
+	Hs
		671540 EPHA6_HUMAN (653-1297): 7.23e-167: 528: 23.27		ECHM_HUMAN (1-292): 1.26e-79: 258: 24.83
+	Hs
		384922 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		HCDH_HUMAN (361-640): 4.08e-120: 365: 32.99
+	Hs
		384338 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		ECHM_HUMAN (1-292): 1.26e-79: 258: 24.83
+	Hs
		384748 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		ECH1_HUMAN (52-221): 1.22e-14: 77.8: 31.87