HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 780
+	Hs
		411361 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		435549 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		435529 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		435620 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		411278 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		411297 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		411311 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		411291 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		411363 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Rn
		783510 T2CB11_RAT (17-1365): 0: 1215: 55.55		PTN11_RAT (7-351): 1.11e-123: 385: 31.48
+	Hs
		411290 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Hs
		537715 INSRR_HUMAN (14-1310): 0: 1170: 55.26		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		435558 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		PTN7_HUMAN (58-298): 7.19e-43: 161: 38.93
+	Hs
		411394 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		411298 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		411401 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTPRO_HUMAN (58-303): 3.31e-46: 180: 38.71
+	Hs
		411369 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Dm
		448231 INSR_DROME (12-1356): 0: 910: 32.97		LAR_DROME (8-302): 1.8e-92: 319: 30.33
+	Dm
		448233 INSR_DROME (12-1356): 0: 910: 32.97		PTP99_DROME (10-319): 2.98e-44: 174: 21.07
+	Hs
		872635 EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48