HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.946

The method score is based on:

Property Details
Experiments 9369444, 12697834, 9506989, 8776723, 8764099, 19165858
Identification Methods two hybrid, affinity chromatography technology, pull down
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~fn3, BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005158 - insulin receptor binding
GO:0005886 - plasma membrane
GO:0008286 - insulin receptor signaling pathway
GO:0048009 - insulin-like growth factor receptor signaling pathway
GO:0120162 - positive regulation of cold-induced thermogenesis
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1367
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024