HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: GRB14 (Q14449)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	21988832
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3, BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0008286 - insulin receptor signaling pathway GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 540
+	Hs
		435632 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		GRB10_HUMAN (5-540): 0: 551: 54.94
+	Hs
		411376 INSR_HUMAN (32-1365): 0: 1219: 56.54		GRB10_HUMAN (5-540): 0: 551: 54.94
+	Hs
		435801 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		VAV3_HUMAN (102-534): 1.45e-85: 284: 13.03
+	Hs
		433523 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		LYN_HUMAN (351-539): 6.38e-42: 159: 18.59
+	Hs
		411288 INSR_HUMAN (32-1365): 0: 1219: 56.54		VAV_HUMAN (100-534): 8.93e-99: 319: 16.35
+	Hs
		435573 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		MATK_HUMAN (399-531): 2.04e-35: 140: 28.89
+	Hs
		435570 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		CSK_HUMAN (398-533): 1.07e-30: 126: 28.26
+	Hs
		435602 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		435620 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Hs
		435546 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Mm
		1141339 IGF1R_MOUSE (1-1367): 0: 1386: 94.98		GRB10_MOUSE (5-88): 2.67e-15: 80.7: 28.57
+	Hs
		435549 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		PTN6_HUMAN (421-523): 1.14e-14: 78.7: 26.79
+	Hs
		411292 INSR_HUMAN (32-1365): 0: 1219: 56.54		PLCG1_HUMAN (238-540): 2.64e-43: 167: 17.67
+	Hs
		411329 INSR_HUMAN (32-1365): 0: 1219: 56.54		CSK_HUMAN (398-533): 1.07e-30: 126: 28.26
+	Hs
		411352 INSR_HUMAN (32-1365): 0: 1219: 56.54		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		411363 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Hs
		411306 INSR_HUMAN (32-1365): 0: 1219: 56.54		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Mm
		546262 INSR_MOUSE (20-1365): 0: 1219: 56.40		P85A_MOUSE (315-535): 4.26e-19: 93: 14.60
+	Mm
		546274 INSR_MOUSE (20-1365): 0: 1219: 56.40		GRB10_MOUSE (5-88): 2.67e-15: 80.7: 28.57
+	Hs
		411311 INSR_HUMAN (32-1365): 0: 1219: 56.54		PTN6_HUMAN (421-523): 1.14e-14: 78.7: 26.79