HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: DUS19 (Q8WTR2)
Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1)
Gene: DUSP19

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DSPc~fn3
Common GO terms	GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 217
+	Hs
		304908 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		DUS14_HUMAN (62-216): 2.26e-65: 202: 30.32
+	Hs
		435706 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		SSH1_HUMAN (66-217): 2.23e-57: 197: 36.31
+	Hs
		435698 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		DUS18_HUMAN (49-216): 1.14e-60: 189: 27.98
+	Hs
		435762 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		DUS21_HUMAN (58-216): 7.05e-59: 185: 29.56
+	Hs
		435704 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		435757 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		DUS15_HUMAN (69-200): 4.44e-55: 178: 37.12
+	Hs
		435748 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		DUS26_HUMAN (63-205): 1.64e-55: 177: 30.20
+	Hs
		435671 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		DUS29_HUMAN (64-204): 1.58e-53: 172: 30.20
+	Hs
		411449 INSR_HUMAN (32-1365): 0: 1219: 56.54		DUS19_HUMAN (1-217): 8.11e-89: 262: 100.00
+	Hs
		304907 INSR_HUMAN (32-1365): 0: 1219: 56.54		DUS14_HUMAN (62-216): 2.26e-65: 202: 30.32
+	Hs
		411454 INSR_HUMAN (32-1365): 0: 1219: 56.54		SSH1_HUMAN (66-217): 2.23e-57: 197: 36.31
+	Hs
		411444 INSR_HUMAN (32-1365): 0: 1219: 56.54		DUS18_HUMAN (49-216): 1.14e-60: 189: 27.98
+	Hs
		411451 INSR_HUMAN (32-1365): 0: 1219: 56.54		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		537762 INSRR_HUMAN (14-1310): 0: 1170: 55.26		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		665410 EPHA3_HUMAN (666-1311): 0: 564: 24.96		DUS18_HUMAN (49-216): 1.14e-60: 189: 27.98
+	Hs
		665430 EPHA3_HUMAN (666-1311): 0: 564: 24.96		DUS21_HUMAN (58-216): 7.05e-59: 185: 29.56
+	Hs
		665415 EPHA3_HUMAN (666-1311): 0: 564: 24.96		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		1072555 EPHA7_HUMAN (656-1342): 1.15e-177: 555: 23.39		DUS18_HUMAN (49-216): 1.14e-60: 189: 27.98
+	Hs
		1072561 EPHA7_HUMAN (656-1342): 1.15e-177: 555: 23.39		STYX_HUMAN (42-215): 5.73e-57: 181: 29.83
+	Hs
		1072585 EPHA7_HUMAN (656-1342): 1.15e-177: 555: 23.39		DUS26_HUMAN (63-205): 1.64e-55: 177: 30.20