HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: FERM2 (Q96AC1)
Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)
Gene: FERMT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0030335 - positive regulation of cell migration GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1367 Hs			1 680
+	Hs
		872687 EPHA4_HUMAN (655-1342): 8.85e-179: 558: 23.12		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		1072570 EPHA7_HUMAN (656-1342): 1.15e-177: 555: 23.39		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		385312 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		508139 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		1081562 NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		665642 EPHB2_HUMAN (496-674): 6.85e-19: 95.5: 17.88		FERM2_HUMAN (1-680): 0: 1112: 100.00
+	Hs
		385775 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		TLN1_HUMAN (485-670): 1.37e-56: 211: 23.15