HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0016020 - membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1367 Hs			1 889
+	Hs
		411491 INSR_HUMAN (32-1365): 0: 1219: 56.54		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		537771 INSRR_HUMAN (14-1310): 0: 1170: 55.26		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		537772 INSRR_HUMAN (14-1310): 0: 1170: 55.26		OSBL5_HUMAN (32-889): 0: 1012: 54.21
+	Hs
		435736 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		435750 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		665522 EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		1318012 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		385477 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		508182 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		1081595 NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		445877 ROS1_HUMAN (691-919): 7.36e-11: 69.4: 17.47		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		665524 EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87		OSBL2_HUMAN (323-758): 4.85e-138: 421: 23.19
+	Hs
		385387 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		508159 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		384259 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42
+	Hs
		603057 NTRK3_HUMAN (977-1262): 5.74e-64: 236: 39.16		OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42
+	Hs
		385465 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		508177 FGFR1_HUMAN (972-1266): 1.32e-64: 238: 39.54		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62