HitPredict

Interactor 1: OPSD (P08100)
Rhodopsin (Opsin-2)
Gene: RHO

Interactor 2: ARBK1 (P25098)
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)
Gene: GRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10722682
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~Pkinase
Common GO terms	GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 348 Hs			1 689
+	Hs
		428923 ADRB2_HUMAN (1-329): 3.47e-73: 234: 16.90		ARBK1_HUMAN (1-689): 0: 654: 100.00
+	Hs
		428943 ADRB2_HUMAN (1-329): 3.47e-73: 234: 16.90		ARBK2_HUMAN (1-685): 0: 638: 84.09
+	Hs
		626625 AGTR1_HUMAN (32-348): 7.05e-65: 210: 19.94		ARBK1_HUMAN (1-689): 0: 654: 100.00
+	Hs
		626645 GPR17_HUMAN (1-325): 1.4e-18: 87.4: 24.41		ARBK1_HUMAN (1-689): 0: 654: 100.00
+	Hs
		435867 OPSD_HUMAN (1-348): 1.07e-82: 256: 100.00		GRK1_HUMAN (2-530): 3.99e-148: 444: 32.60
+	Bt
		362127 OPSD_BOVIN (1-348): 6.07e-89: 272: 93.39		GRK1_BOVIN (2-562): 1.88e-137: 416: 29.91
+	Mm
		250677 OPSD_MOUSE (1-348): 1.76e-86: 266: 94.83		GRK6_MOUSE (3-543): 7.74e-137: 415: 36.61
+	Hs
		429053 ADRB2_HUMAN (1-329): 3.47e-73: 234: 16.90		GRK1_HUMAN (2-530): 3.99e-148: 444: 32.60
+	Hs
		435865 OPSD_HUMAN (1-348): 1.07e-82: 256: 100.00		GRK5_HUMAN (3-567): 1.49e-136: 415: 33.86
+	Hs
		428935 ADRB2_HUMAN (1-329): 3.47e-73: 234: 16.90		GRK4_HUMAN (3-594): 3.18e-140: 424: 33.33
+	Hs
		428959 ADRB2_HUMAN (1-329): 3.47e-73: 234: 16.90		GRK6_HUMAN (3-543): 2.29e-139: 422: 36.25
+	Hs
		428938 ADRB2_HUMAN (1-329): 3.47e-73: 234: 16.90		GRK5_HUMAN (3-567): 1.49e-136: 415: 33.86
+	Hs
		626733 NK1R_HUMAN (8-340): 1.03e-68: 222: 22.06		GRK5_HUMAN (3-567): 1.49e-136: 415: 33.86
+	Hs
		674828 AGTR1_HUMAN (32-348): 7.05e-65: 210: 19.94		GRK5_HUMAN (3-567): 1.49e-136: 415: 33.86