HitPredict

Interactor 1: FCGR2 (P08101)
Low affinity immunoglobulin gamma Fc region receptor II (Fc gamma receptor IIB) (Fc-gamma RII) (Fc-gamma-RIIB) (FcRII) (IgG Fc receptor II beta) (Lymphocyte antigen 17) (Ly-17) (CD antigen CD32)
Gene: FCGR2

Interactor 2: SHIP1 (Q9ES52)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)
Gene: Inpp5d

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	9973396
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016064 - immunoglobulin mediated immune response GO:0030889 - negative regulation of B cell proliferation GO:0050777 - negative regulation of immune response
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 330 Mm			1 1191
+	Rn
		956853 FCGR2_RAT (1-330): 7.49e-69: 218: 67.77		SHIP1_RAT (1-1191): 0: 925: 96.56
+	Hs
		1268705 FCGRB_HUMAN (14-240): 3.57e-76: 237: 38.26		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Mm
		722908 CD22_MOUSE (29-265): 3.5e-20: 93.4: 14.60		SHIP1_MOUSE (1-1191): 0: 930: 100.00
+	Hs
		590610 CD22_HUMAN (2-118): 5.85e-14: 74.5: 22.76		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		685209 FCG2B_HUMAN (2-99): 1.64e-10: 63.2: 17.00		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		155860 ROBO1_HUMAN (2-308): 4.28e-42: 157: 14.85		SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33
+	Hs
		243129 CD22_HUMAN (2-118): 5.85e-14: 74.5: 22.76		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		243132 FCG2B_HUMAN (2-99): 1.64e-10: 63.2: 17.00		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21