HitPredict

Interactor 1: HCK (P08103)
Tyrosine-protein kinase HCK (EC 2.7.10.2) (B-cell/myeloid kinase) (BMK) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p56-HCK/p59-HCK)
Gene: HCK

Interactor 2: SH21C (Q45HK4)
SH2 domain-containing protein 1B2 (EAT-2-related transducer) (ERT) (EAT-2B)
Gene: Sh2d1b2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16425036
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 524 Mm			1 132
+	Mm
		435875 HCK_MOUSE (1-524): 0: 651: 100.00		HCK_MOUSE (4-127): 1.46e-35: 129: 24.62
+	Hs
		442759 HCK_HUMAN (1-524): 0: 646: 89.54		HCK_HUMAN (4-127): 1.04e-35: 130: 26.92
+	Hs
		442789 HCK_HUMAN (1-524): 0: 646: 89.54		ABL2_HUMAN (5-126): 3.99e-35: 129: 27.05
+	Hs
		337315 HCK_HUMAN (1-524): 0: 646: 89.54		ABL1_HUMAN (5-126): 9.52e-35: 128: 26.23
+	Hs
		442867 HCK_HUMAN (1-524): 0: 646: 89.54		SHIP1_HUMAN (5-132): 1.06e-34: 128: 28.91
+	Hs
		442772 HCK_HUMAN (1-524): 0: 646: 89.54		SRC_HUMAN (4-127): 9.53e-35: 127: 26.92
+	Hs
		411559 HCK_HUMAN (1-524): 0: 646: 89.54		LCK_HUMAN (4-127): 3.02e-34: 125: 26.92
+	Hs
		433530 HCK_HUMAN (1-524): 0: 646: 89.54		LYN_HUMAN (4-126): 1.08e-33: 124: 22.48
+	Mm
		763392 FYN_MOUSE (11-522): 0: 599: 56.20		SH21C_MOUSE (1-132): 2.98e-42: 137: 100.00
+	Hs
		411936 FYN_HUMAN (11-522): 0: 600: 56.39		FYN_HUMAN (4-127): 1.51e-36: 132: 26.15
+	Hs
		411946 FYN_HUMAN (11-522): 0: 600: 56.39		YES_HUMAN (4-127): 2.82e-36: 131: 23.85
+	Hs
		412070 FYN_HUMAN (11-522): 0: 600: 56.39		ABL2_HUMAN (5-126): 3.99e-35: 129: 27.05
+	Hs
		337307 FYN_HUMAN (11-522): 0: 600: 56.39		ABL1_HUMAN (5-126): 9.52e-35: 128: 26.23
+	Hs
		411969 FYN_HUMAN (11-522): 0: 600: 56.39		SRC_HUMAN (4-127): 9.53e-35: 127: 26.92
+	Hs
		412071 FYN_HUMAN (11-522): 0: 600: 56.39		FRK_HUMAN (4-131): 5.07e-35: 127: 25.58
+	Hs
		411545 FYN_HUMAN (11-522): 0: 600: 56.39		LCK_HUMAN (4-127): 3.02e-34: 125: 26.92
+	Mm
		292397 FYN_MOUSE (11-522): 0: 599: 56.20		SH21A_MOUSE (6-121): 4.81e-37: 124: 37.93
+	Hs
		412066 FYN_HUMAN (11-522): 0: 600: 56.39		CSK_HUMAN (3-100): 4.11e-32: 119: 30.61
+	Hs
		243121 FYN_HUMAN (11-522): 0: 600: 56.39		SH21A_HUMAN (6-124): 1.35e-33: 115: 38.66
+	Hs
		412076 FYN_HUMAN (11-522): 0: 600: 56.39		KSYK_HUMAN (3-128): 4.23e-16: 75.1: 25.98