HitPredict

Interactor 1: CO3A1 (P08121)
Collagen alpha-1(III) chain
Gene: Col3a1

Interactor 2: SMAD4 (P97471)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
Gene: SMAD4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14559231
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001701 - in utero embryonic development GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0046332 - SMAD binding GO:0046872 - metal ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1464 Mm			1 551
+	Mm
		503173 CO1A1_MOUSE (25-1464): 0: 652: 59.40		SMAD4_MOUSE (1-551): 0: 702: 100.00
+	Hs
		358510 CO1A1_HUMAN (24-1464): 0: 638: 60.47		SMAD4_HUMAN (1-551): 0: 694: 98.37
+	Mm
		503178 CO1A1_MOUSE (25-1464): 0: 652: 59.40		SMAD3_MOUSE (19-548): 1.83e-171: 493: 31.65
+	Mm
		435992 CO3A1_MOUSE (1-1464): 0: 586: 99.59		SMAD1_MOUSE (20-545): 0: 552: 34.41
+	Hs
		358494 CO1A1_HUMAN (24-1464): 0: 638: 60.47		SMAD3_HUMAN (19-548): 1.83e-171: 493: 31.65
+	Mm
		503177 CO1A1_MOUSE (25-1464): 0: 652: 59.40		SMAD2_MOUSE (19-548): 2.61e-163: 474: 28.89
+	Hs
		358519 CO1A1_HUMAN (24-1464): 0: 638: 60.47		SMAD2_HUMAN (19-548): 2.08e-162: 472: 28.89
+	Mm
		435996 CO3A1_MOUSE (1-1464): 0: 586: 99.59		SMAD3_MOUSE (19-548): 1.83e-171: 493: 31.65
+	Mm
		435995 CO3A1_MOUSE (1-1464): 0: 586: 99.59		SMAD2_MOUSE (19-548): 2.61e-163: 474: 28.89
+	Mm
		291323 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD4_MOUSE (1-551): 0: 702: 100.00
+	Mm
		192481 CO1A1_MOUSE (25-1464): 0: 652: 59.40		SMAD7_MOUSE (37-181): 6.43e-33: 132: 20.59
+	Mm
		192480 CO3A1_MOUSE (1-1464): 0: 586: 99.59		SMAD7_MOUSE (37-181): 6.43e-33: 132: 20.59
+	Mm
		291322 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD1_MOUSE (20-545): 0: 552: 34.41
+	Mm
		291326 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD3_MOUSE (19-548): 1.83e-171: 493: 31.65
+	Mm
		291325 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD2_MOUSE (19-548): 2.61e-163: 474: 28.89
+	Mm
		192478 CO5A1_MOUSE (18-486): 1.25e-23: 111: 36.89		SMAD7_MOUSE (37-181): 6.43e-33: 132: 20.59