HitPredict

Interactor 1: CO1A2 (P08123)
Collagen alpha-2(I) chain (Alpha-2 type I collagen)
Gene: COL1A2

Interactor 2: MMP2 (P08253)
72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]
Gene: MMP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0030198 - extracellular matrix organization GO:0062023 - collagen-containing extracellular matrix GO:0071230 - cellular response to amino acid stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1366 Hs			1 660
+	Hs
		436005 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP9_HUMAN (21-660): 0: 711: 44.40
+	Hs
		358454 CO1A1_HUMAN (20-1019): 8.86e-96: 340: 42.91		MMP2_HUMAN (1-660): 0: 912: 100.00
+	Hs
		358587 CO2A1_HUMAN (412-1174): 1.06e-85: 310: 34.44		MMP2_HUMAN (1-660): 0: 912: 100.00
+	Hs
		439227 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		MMP2_HUMAN (1-660): 0: 912: 100.00
+	Hs
		439220 CO4A2_HUMAN (2-294): 2.25e-27: 123: 29.91		MMP2_HUMAN (1-660): 0: 912: 100.00
+	Hs
		436002 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP3_HUMAN (18-229): 4.24e-90: 290: 44.95
+	Hs
		439240 CO4A6_HUMAN (2-291): 7.64e-27: 121: 30.62		MMP2_HUMAN (1-660): 0: 912: 100.00
+	Hs
		358647 CO4A1_HUMAN (2-287): 9.69e-24: 111: 28.13		MMP2_HUMAN (1-660): 0: 912: 100.00
+	Hs
		358595 CO2A1_HUMAN (412-1174): 1.06e-85: 310: 34.44		MMP9_HUMAN (21-660): 0: 711: 44.40
+	Hs
		372723 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP1_HUMAN (34-230): 8.32e-84: 273: 42.11
+	Hs
		436012 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP8_HUMAN (42-230): 4.19e-78: 258: 41.50
+	Hs
		436025 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP16_HUMAN (50-229): 1.38e-71: 244: 35.78
+	Hs
		436022 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP14_HUMAN (51-519): 6.63e-70: 239: 21.09
+	Hs
		436024 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP15_HUMAN (41-229): 7.87e-69: 238: 33.80
+	Hs
		540415 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		MMP9_HUMAN (21-660): 0: 711: 44.40
+	Hs
		441053 CO4A2_HUMAN (2-294): 2.25e-27: 123: 29.91		MMP9_HUMAN (21-660): 0: 711: 44.40
+	Hs
		358650 CO4A1_HUMAN (2-287): 9.69e-24: 111: 28.13		MMP9_HUMAN (21-660): 0: 711: 44.40
+	Hs
		358441 CO1A1_HUMAN (20-1019): 8.86e-96: 340: 42.91		FINC_HUMAN (255-405): 8.74e-31: 131: 42.24
+	Hs
		362809 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		FINC_HUMAN (255-405): 8.74e-31: 131: 42.24
+	Hs
		363093 CO7A1_HUMAN (907-1182): 3.11e-15: 83.7: 30.20		FINC_HUMAN (255-405): 8.74e-31: 131: 42.24