HitPredict

Interactor 1: CO1A2 (P08123)
Collagen alpha-2(I) chain (Alpha-2 type I collagen)
Gene: COL1A2

Interactor 2: MMP9 (P14780)
Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
Gene: MMP9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001501 - skeletal system development GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0030198 - extracellular matrix organization GO:0062023 - collagen-containing extracellular matrix and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1366 Hs			1 707
+	Hs
		358595 CO2A1_HUMAN (412-1174): 1.06e-85: 310: 34.44		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		540415 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		436002 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP3_HUMAN (8-272): 4.38e-93: 299: 37.46
+	Hs
		372723 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67
+	Hs
		436012 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP8_HUMAN (35-295): 3.17e-81: 267: 32.01
+	Hs
		436025 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP16_HUMAN (45-280): 2.33e-72: 248: 32.35
+	Hs
		441053 CO4A2_HUMAN (2-294): 2.25e-27: 123: 29.91		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		436022 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP14_HUMAN (33-254): 2.47e-70: 241: 32.43
+	Hs
		436024 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP15_HUMAN (45-279): 2.87e-67: 235: 31.02
+	Hs
		358650 CO4A1_HUMAN (2-287): 9.69e-24: 111: 28.13		MMP9_HUMAN (1-707): 0: 862: 100.00
+	Hs
		436001 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		358454 CO1A1_HUMAN (20-1019): 8.86e-96: 340: 42.91		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		358441 CO1A1_HUMAN (20-1019): 8.86e-96: 340: 42.91		FINC_HUMAN (202-387): 5.44e-16: 84.8: 26.80
+	Hs
		358587 CO2A1_HUMAN (412-1174): 1.06e-85: 310: 34.44		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		439227 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		362809 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		FINC_HUMAN (202-387): 5.44e-16: 84.8: 26.80
+	Hs
		439220 CO4A2_HUMAN (2-294): 2.25e-27: 123: 29.91		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		439240 CO4A6_HUMAN (2-291): 7.64e-27: 121: 30.62		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		358647 CO4A1_HUMAN (2-287): 9.69e-24: 111: 28.13		MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71
+	Hs
		363093 CO7A1_HUMAN (907-1182): 3.11e-15: 83.7: 30.20		FINC_HUMAN (202-387): 5.44e-16: 84.8: 26.80