HitPredict

Interactor 1: CO1A2 (P08123)
Collagen alpha-2(I) chain (Alpha-2 type I collagen)
Gene: COL1A2

Interactor 2: MMP16 (P51512)
Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)
Gene: MMP16

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001501 - skeletal system development GO:0005615 - extracellular space GO:0030198 - extracellular matrix organization
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1366 Hs			1 607
+	Hs
		436022 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP14_HUMAN (30-607): 0: 703: 54.75
+	Hs
		436024 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP15_HUMAN (34-607): 0: 692: 52.24
+	Hs
		436002 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP3_HUMAN (26-532): 0: 568: 34.42
+	Hs
		372723 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP1_HUMAN (30-535): 0: 552: 35.35
+	Hs
		436012 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP8_HUMAN (31-532): 0: 545: 34.71
+	Hs
		436001 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP2_HUMAN (30-231): 7.75e-76: 256: 36.14
+	Hs
		436005 CO1A2_HUMAN (1-1366): 0: 743: 100.00		MMP9_HUMAN (23-231): 2.47e-63: 223: 36.19
+	Hs
		358454 CO1A1_HUMAN (20-1019): 8.86e-96: 340: 42.91		MMP2_HUMAN (30-231): 7.75e-76: 256: 36.14
+	Hs
		358587 CO2A1_HUMAN (412-1174): 1.06e-85: 310: 34.44		MMP2_HUMAN (30-231): 7.75e-76: 256: 36.14
+	Hs
		358595 CO2A1_HUMAN (412-1174): 1.06e-85: 310: 34.44		MMP9_HUMAN (23-231): 2.47e-63: 223: 36.19
+	Hs
		439227 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		MMP2_HUMAN (30-231): 7.75e-76: 256: 36.14
+	Hs
		540415 CO5A1_HUMAN (1-928): 1.07e-67: 254: 43.30		MMP9_HUMAN (23-231): 2.47e-63: 223: 36.19
+	Hs
		439220 CO4A2_HUMAN (2-294): 2.25e-27: 123: 29.91		MMP2_HUMAN (30-231): 7.75e-76: 256: 36.14
+	Hs
		439240 CO4A6_HUMAN (2-291): 7.64e-27: 121: 30.62		MMP2_HUMAN (30-231): 7.75e-76: 256: 36.14
+	Hs
		358647 CO4A1_HUMAN (2-287): 9.69e-24: 111: 28.13		MMP2_HUMAN (30-231): 7.75e-76: 256: 36.14
+	Hs
		441053 CO4A2_HUMAN (2-294): 2.25e-27: 123: 29.91		MMP9_HUMAN (23-231): 2.47e-63: 223: 36.19
+	Hs
		358650 CO4A1_HUMAN (2-287): 9.69e-24: 111: 28.13		MMP9_HUMAN (23-231): 2.47e-63: 223: 36.19