HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~TIG
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1390
+	Hs
		441478 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		872423 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08
+	Hs
		436223 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08
+	Hs
		872424 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08
+	Hs
		900497 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53
+	Hs
		925297 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53
+	Hs
		436317 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53
+	Hs
		872518 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72
+	Hs
		872522 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72
+	Hs
		436224 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72
+	Hs
		195972 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		PLXB1_HUMAN (464-1030): 8.24e-66: 248: 20.88
+	Hs
		165182 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57
+	Hs
		165187 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57
+	Hs
		165146 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57
+	Hs
		165189 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57
+	Hs
		901031 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		PLXA1_HUMAN (461-1020): 8.14e-54: 209: 20.36
+	Hs
		925714 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		PLXA1_HUMAN (461-1020): 8.14e-54: 209: 20.36
+	Hs
		436563 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		PLXA1_HUMAN (461-1020): 8.14e-54: 209: 20.36
+	Rn
		71354 B2RYP0_RAT (1-193): 4.65e-80: 238: 99.48		INSR_RAT (1084-1335): 3.22e-52: 204: 40.98
+	Dm
		776907 RAC1_DROME (1-193): 2.47e-78: 233: 54.12		PLXB_DROME (565-1035): 5.54e-22: 105: 14.37