HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	17353931, 35271311, 36192543
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 204
+	Rn
		901290 RHOA_RAT (1-193): 7.11e-82: 242: 92.23		GDIR1_RAT (1-204): 6.26e-117: 332: 97.06
+	Hs
		854763 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Hs
		854769 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Mm
		925816 RAC1_MOUSE (1-193): 7.23e-81: 240: 57.22		GDIR1_MOUSE (1-204): 6.26e-117: 332: 97.06
+	Hs
		854771 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Hs
		854760 CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Hs
		545278 RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	Hs
		854767 RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82		GDIR1_HUMAN (1-204): 5.03e-117: 332: 100.00
+	At
		1105129 RAC3_ARATH (2-193): 2.18e-92: 269: 48.99		GDIR_ARATH (2-202): 4.35e-89: 263: 37.86
+	Hs
		854851 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		900840 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05
+	Hs
		925561 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05
+	Hs
		854852 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		951270 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05
+	Hs
		545279 RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		894357 CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30		GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05
+	Hs
		915920 RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82		GDIR3_HUMAN (15-204): 5.87e-96: 280: 61.05
+	Sc
		419734 RHO1_YEAST (3-179): 1.62e-95: 278: 74.01		GDIR_YEAST (19-200): 5.15e-69: 211: 37.90
+	Cl
		47354 RAC1_CANLF (1-193): 7.23e-81: 240: 57.22		A0A8I3N6C6_CANLF (1-204): 3.52e-81: 240: 76.47
+	Ce
		975573 RAC1_CAEEL (1-193): 2.88e-81: 241: 53.89		GDIR_CAEEL (20-201): 2.64e-75: 226: 38.80