HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: ROCK1 (Q13464)
Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)
Gene: ROCK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34285210, 31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras, Ras~Rho_Binding
Common GO terms	GO:0000281 - mitotic cytokinesis GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0032956 - regulation of actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1354
+	Hs
		900444 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		ROCK1_HUMAN (1-1354): 0: 886: 100.00
+	Hs
		925253 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		ROCK1_HUMAN (1-1354): 0: 886: 100.00
+	Hs
		254464 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		ROCK2_HUMAN (7-1344): 0: 714: 64.97
+	Hs
		254468 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		ROCK2_HUMAN (7-1344): 0: 714: 64.97
+	Hs
		254433 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		ROCK2_HUMAN (7-1344): 0: 714: 64.97
+	Dm
		776923 RAC1_DROME (1-193): 2.47e-78: 233: 54.12		Q9VXE3_DROME (9-1347): 0: 615: 42.66
+	Dm
		776931 RAC1_DROME (1-193): 2.47e-78: 233: 54.12		X2JE40_DROME (9-1341): 0: 605: 42.63
+	Hs
		148608 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		CTRO_HUMAN (13-1292): 1.39e-130: 447: 20.62
+	Hs
		148653 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		CTRO_HUMAN (13-1292): 1.39e-130: 447: 20.62
+	Hs
		148297 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		CTRO_HUMAN (13-1292): 1.39e-130: 447: 20.62
+	Hs
		925229 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		DMPK_HUMAN (6-522): 1.31e-127: 410: 35.15
+	Hs
		850632 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		KS6A3_HUMAN (6-381): 3.43e-86: 299: 23.64
+	Hs
		900570 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		MRCKA_HUMAN (668-1327): 3.6e-64: 242: 12.45
+	Hs
		925344 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		MRCKA_HUMAN (668-1327): 3.6e-64: 242: 12.45
+	Hs
		925356 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		MRCKG_HUMAN (653-1224): 5.7e-42: 171: 11.43
+	Mm
		823539 RHOA_MOUSE (1-193): 7.11e-82: 242: 92.23		CTRO_MOUSE (711-1252): 2.79e-28: 126: 13.42
+	Mm
		823530 RAC1_MOUSE (1-193): 7.23e-81: 240: 57.22		CTRO_MOUSE (711-1252): 2.79e-28: 126: 13.42
+	Rn
		92842 RHOA_RAT (1-193): 7.11e-82: 242: 92.23		CTRO_RAT (331-953): 1.27e-26: 121: 10.99
+	Hs
		901094 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		MRCKB_HUMAN (806-1251): 1.11e-22: 108: 12.31
+	Hs
		925766 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		MRCKB_HUMAN (806-1251): 1.11e-22: 108: 12.31