HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1919
+	Hs
		900722 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Hs
		925457 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Hs
		951180 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Hs
		900762 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		DLG3_HUMAN (1133-1916): 5.4e-177: 560: 18.97
+	Hs
		951207 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		DLG3_HUMAN (1133-1916): 5.4e-177: 560: 18.97
+	Hs
		900424 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		925239 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Mm
		925797 RAC1_MOUSE (1-193): 7.23e-81: 240: 57.22		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Hs
		436278 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		950954 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		893948 CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		900562 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		MPP7_HUMAN (1465-1915): 4.41e-107: 356: 20.37
+	Hs
		925341 RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22		MPP7_HUMAN (1465-1915): 4.41e-107: 356: 20.37
+	Hs
		436349 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		MPP7_HUMAN (1465-1915): 4.41e-107: 356: 20.37
+	Hs
		951060 RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92		MPP7_HUMAN (1465-1915): 4.41e-107: 356: 20.37
+	Hs
		900683 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		PALS1_HUMAN (1501-1916): 9.35e-98: 333: 19.50
+	Hs
		901012 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		436557 RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		900411 RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81
+	Hs
		893933 CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81