HitPredict

Interactor 1: TNR16 (P08138)
Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271)
Gene: NGFR

Interactor 2: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	10514511
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 427 Hs			1 501
+	Rn
		78206 TNR16_RAT (3-427): 3.25e-110: 332: 92.24		B5DFH7_RAT (1-501): 1.66e-151: 443: 86.43
+	Mm
		626852 TNR1A_MOUSE (29-425): 1.22e-78: 252: 17.33		TRAF2_MOUSE (1-501): 9.33e-158: 459: 86.83
+	Hs
		584390 TNR1A_HUMAN (29-417): 1.27e-76: 247: 18.27		TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00
+	Hs
		129526 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		TRAF5_HUMAN (7-501): 1.93e-115: 353: 30.90
+	Hs
		436620 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31
+	Hs
		436651 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08
+	Hs
		154352 TR10B_HUMAN (17-424): 1.06e-61: 207: 16.08		TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00
+	Rn
		78177 TNR16_RAT (3-427): 3.25e-110: 332: 92.24		TRAF6_RAT (4-498): 1.62e-109: 336: 28.37
+	Hs
		1020849 TNR25_HUMAN (29-422): 1.33e-58: 198: 18.75		TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00
+	Hs
		436641 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		TRAF4_HUMAN (17-498): 1.52e-94: 296: 29.12
+	Hs
		591317 TNR1B_HUMAN (8-274): 1.53e-45: 165: 18.32		TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00
+	Hs
		436619 TNR16_HUMAN (1-427): 1.17e-115: 346: 100.00		TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44
+	Mm
		648951 TNR5_MOUSE (13-254): 3.01e-46: 162: 23.90		TRAF2_MOUSE (1-501): 9.33e-158: 459: 86.83
+	Hs
		584394 TNR1A_HUMAN (29-417): 1.27e-76: 247: 18.27		TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31
+	Hs
		584509 TNR1A_HUMAN (29-417): 1.27e-76: 247: 18.27		TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08
+	Hs
		584392 TNR1A_HUMAN (29-417): 1.27e-76: 247: 18.27		TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44
+	Hs
		591320 TNR1B_HUMAN (8-274): 1.53e-45: 165: 18.32		TRAF3_HUMAN (14-501): 2.21e-112: 345: 31.31
+	Mm
		648955 TNR5_MOUSE (13-254): 3.01e-46: 162: 23.90		TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87
+	Hs
		591438 TNR1B_HUMAN (8-274): 1.53e-45: 165: 18.32		TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08
+	Hs
		591319 TNR1B_HUMAN (8-274): 1.53e-45: 165: 18.32		TRAF1_HUMAN (130-499): 1.15e-88: 279: 37.44