HitPredict

Interactor 1: GLI1 (P08151)
Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)
Gene: GLI1

Interactor 2: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	30389910, 23446420
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, protein kinase assay, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	Pkinase~zf-C2H2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0046872 - metal ion binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1106 Hs			1 596
+	Hs
		436674 GLI1_HUMAN (1-1106): 0: 620: 100.00		KS6B1_HUMAN (215-594): 1.3e-145: 432: 35.94
+	Hs
		682014 GLIS2_HUMAN (237-384): 4.86e-43: 167: 58.39		AKT1_HUMAN (181-586): 1.34e-151: 446: 37.86
+	Hs
		485103 GLI3_HUMAN (3-1105): 1.41e-161: 521: 30.43		KPCA_HUMAN (111-223): 4.34e-17: 86.9: 24.37