HitPredict

Interactor 1: IDH (P08200)
Isocitrate dehydrogenase [NADP] (IDH) (EC 1.1.1.42) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)
Gene: icd

Interactor 2: ACEK (P11071)
Isocitrate dehydrogenase kinase/phosphatase (IDH kinase/phosphatase) (IDHK/P) (EC 2.7.11.5) (EC 3.1.3.-)
Gene: ACEK

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.90	0.812

Property	Details
Experiments	24561554, 20505668
Identification Methods	two hybrid, phosphatase assay, molecular sieving, x-ray crystallography, protein kinase assay, two hybrid array
Interaction Type	direct interaction, dephosphorylation reaction, phosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	AceK_kinase~Iso_dh
Common GO terms	GO:0000287 - magnesium ion binding GO:0005737 - cytoplasm GO:0006097 - glyoxylate cycle GO:0006099 - tricarboxylic acid cycle
Homologous interactions	0