HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: RAG1 (P15918)
V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74) [Includes: Endonuclease RAG1 (EC 3.1.-.-); E3 ubiquitin-protein ligase RAG1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAG1)]
Gene: RAG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1043
+	Hs
		431502 HS90A_HUMAN (1-724): 0: 1072: 85.25		RAG1_HUMAN (1-1043): 0: 1703: 100.00
+	Hs
		438502 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRIM6_HUMAN (279-550): 5.9e-39: 154: 12.54
+	Hs
		438501 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRIM7_HUMAN (288-563): 3.13e-38: 152: 16.83
+	Hs
		437829 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRI49_HUMAN (279-601): 9.82e-38: 149: 15.16
+	Hs
		438654 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRI17_HUMAN (278-461): 2.22e-35: 143: 17.44
+	Hs
		438587 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRI10_HUMAN (278-548): 1.38e-34: 141: 13.94
+	Hs
		432238 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRIM7_HUMAN (288-563): 3.13e-38: 152: 16.83
+	Hs
		431456 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRI49_HUMAN (279-601): 9.82e-38: 149: 15.16
+	Hs
		438500 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRI31_HUMAN (278-550): 3.89e-33: 135: 13.26
+	Mm
		513670 HS90B_MOUSE (1-724): 0: 1089: 99.59		TRAF6_MOUSE (281-451): 5.96e-31: 130: 20.12
+	Hs
		432399 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRI17_HUMAN (278-461): 2.22e-35: 143: 17.44
+	Hs
		432329 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRI10_HUMAN (278-548): 1.38e-34: 141: 13.94
+	Hs
		438379 HS90B_HUMAN (1-724): 0: 1086: 100.00		LNX1_HUMAN (258-402): 6.57e-27: 120: 24.66
+	Mm
		432421 HS90A_MOUSE (1-724): 0: 1068: 84.31		TRAF6_MOUSE (281-451): 5.96e-31: 130: 20.12
+	Hs
		432086 HS90A_HUMAN (1-724): 0: 1072: 85.25		LNX1_HUMAN (258-402): 6.57e-27: 120: 24.66
+	Hs
		62676 ENPL_HUMAN (3-693): 0: 917: 46.44		TRI64_HUMAN (279-593): 7.49e-72: 247: 15.27
+	Hs
		437880 HS90B_HUMAN (1-724): 0: 1086: 100.00		RO52_HUMAN (79-206): 1.07e-12: 73.7: 12.40
+	Hs
		437956 HS90B_HUMAN (1-724): 0: 1086: 100.00		BRCA1_HUMAN (291-361): 2.22e-09: 63.9: 28.77
+	Hs
		431610 HS90A_HUMAN (1-724): 0: 1072: 85.25		BRCA1_HUMAN (291-361): 2.22e-09: 63.9: 28.77
+	Hs
		538133 ENPL_HUMAN (3-693): 0: 917: 46.44		BRCA1_HUMAN (291-361): 2.22e-09: 63.9: 28.77