HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: BMR1A (P36894)
Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
Gene: BMPR1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27684187, 22939624
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0042803 - protein homodimerization activity GO:0043025 - neuronal cell body
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 532
+	Hs
		431601 HS90A_HUMAN (1-724): 0: 1072: 85.25		BMR1A_HUMAN (1-532): 5.05e-164: 477: 100.00
+	Hs
		431603 HS90A_HUMAN (1-724): 0: 1072: 85.25		TGFR1_HUMAN (26-532): 9.84e-139: 412: 49.22
+	Hs
		438363 HS90B_HUMAN (1-724): 0: 1086: 100.00		ACV1C_HUMAN (57-531): 1.11e-133: 398: 50.63
+	Hs
		437952 HS90B_HUMAN (1-724): 0: 1086: 100.00		ACV1B_HUMAN (47-532): 1.83e-128: 385: 49.19
+	Hs
		432072 HS90A_HUMAN (1-724): 0: 1072: 85.25		ACV1C_HUMAN (57-531): 1.11e-133: 398: 50.63
+	Hs
		431602 HS90A_HUMAN (1-724): 0: 1072: 85.25		ACV1B_HUMAN (47-532): 1.83e-128: 385: 49.19
+	Hs
		431606 HS90A_HUMAN (1-724): 0: 1072: 85.25		ACVL1_HUMAN (57-531): 4.4e-128: 385: 45.72
+	Hs
		438157 HS90B_HUMAN (1-724): 0: 1086: 100.00		AVR2B_HUMAN (81-529): 7.14e-111: 341: 30.02
+	Hs
		431607 HS90A_HUMAN (1-724): 0: 1072: 85.25		TGFR2_HUMAN (38-524): 3.81e-115: 353: 27.43
+	Hs
		431836 HS90A_HUMAN (1-724): 0: 1072: 85.25		AVR2B_HUMAN (81-529): 7.14e-111: 341: 30.02
+	Ce
		595733 HSP90_CAEEL (8-724): 0: 976: 74.34		DAF1_CAEEL (74-523): 1.31e-96: 308: 30.39
+	Hs
		438218 HS90B_HUMAN (1-724): 0: 1086: 100.00		AMHR2_HUMAN (235-529): 2.38e-39: 152: 33.23
+	Hs
		431905 HS90A_HUMAN (1-724): 0: 1072: 85.25		AMHR2_HUMAN (235-529): 2.38e-39: 152: 33.23
+	Ce
		839899 HSP90_CAEEL (8-724): 0: 976: 74.34		DAF4_CAEEL (59-514): 7.47e-36: 144: 27.00
+	Hs
		1086118 H90B4_HUMAN (25-596): 0: 639: 71.85		AMHR2_HUMAN (235-529): 2.38e-39: 152: 33.23