HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 450
+	Hs
		337314 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		411949 HS90B_HUMAN (1-724): 0: 1086: 100.00		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		437847 HS90B_HUMAN (1-724): 0: 1086: 100.00		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		433218 HS90B_HUMAN (1-724): 0: 1086: 100.00		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Hs
		411556 HS90B_HUMAN (1-724): 0: 1086: 100.00		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		437966 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33
+	Hs
		437967 HS90B_HUMAN (1-724): 0: 1086: 100.00		FRK_HUMAN (5-442): 1.83e-167: 482: 36.17
+	Hs
		437817 HS90B_HUMAN (1-724): 0: 1086: 100.00		HCK_HUMAN (3-445): 6.38e-167: 481: 36.32
+	Hs
		337312 HS90A_HUMAN (1-724): 0: 1072: 85.25		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		411945 HS90A_HUMAN (1-724): 0: 1072: 85.25		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		69196 HS90B_HUMAN (1-724): 0: 1086: 100.00		A9UEZ6_HUMAN (35-447): 9.24e-154: 477: 39.34
+	Hs
		431433 HS90A_HUMAN (1-724): 0: 1072: 85.25		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Hs
		437823 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGR_HUMAN (12-442): 4.47e-165: 476: 38.43
+	Hs
		411551 HS90A_HUMAN (1-724): 0: 1072: 85.25		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		431445 HS90A_HUMAN (1-724): 0: 1072: 85.25		HCK_HUMAN (3-445): 6.38e-167: 481: 36.32
+	Hs
		437965 HS90B_HUMAN (1-724): 0: 1086: 100.00		MATK_HUMAN (7-440): 2.57e-161: 466: 53.79
+	Hs
		433526 HS90B_HUMAN (1-724): 0: 1086: 100.00		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		438007 HS90B_HUMAN (1-724): 0: 1086: 100.00		BLK_HUMAN (8-445): 3.88e-159: 461: 37.03
+	Hs
		431434 HS90A_HUMAN (1-724): 0: 1072: 85.25		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		438160 HS90B_HUMAN (1-724): 0: 1086: 100.00		PTK6_HUMAN (11-447): 3.62e-149: 433: 35.41