HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: M3K8 (P41279)
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
Gene: MAP3K8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	14743216, 22939624
Identification Methods	tandem affinity purification, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 467
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (31-438): 7.59e-137: 404: 15.46
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (43-466): 1.83e-134: 398: 16.08
+	Hs
		438085 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCE_HUMAN (49-463): 9.48e-132: 399: 16.03
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (80-460): 5.42e-135: 399: 17.22
+	Hs
		431620 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K8_HUMAN (1-467): 9.62e-140: 411: 100.00
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (49-466): 1.05e-133: 396: 16.17
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (49-466): 3.62e-134: 397: 16.17
+	Hs
		438094 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCT_HUMAN (56-453): 1.4e-130: 395: 16.06
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (31-438): 7.59e-137: 404: 15.46
+	Hs
		116958 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK1_HUMAN (101-466): 2.04e-130: 385: 19.74
+	Hs
		431752 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCE_HUMAN (49-463): 9.48e-132: 399: 16.03
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (49-466): 1.05e-133: 396: 16.17
+	Hs
		116956 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGK1_HUMAN (101-466): 2.04e-130: 385: 19.74
+	Hs
		438441 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC1G_HUMAN (119-462): 1.11e-105: 324: 21.97
+	Hs
		131545 HS90B_HUMAN (1-724): 0: 1086: 100.00		STK25_HUMAN (142-436): 4.1e-103: 316: 30.80
+	Hs
		131544 HS90A_HUMAN (1-724): 0: 1072: 85.25		STK25_HUMAN (142-436): 4.1e-103: 316: 30.80
+	Hs
		438461 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K14_HUMAN (107-382): 8.18e-30: 125: 30.66
+	Hs
		438465 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K5_HUMAN (114-426): 1.3e-27: 118: 29.73
+	Hs
		438551 HS90B_HUMAN (1-724): 0: 1086: 100.00		PAK6_HUMAN (144-388): 1.71e-27: 117: 32.67
+	Hs
		438288 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K15_HUMAN (146-384): 6.5e-27: 116: 32.27