HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.516

Property	Details
Experiments	17955473
Identification Methods	pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 156
+	Hs
		431628 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDN2A_HUMAN (1-156): 1.38e-51: 163: 100.00
+	Hs
		438082 HS90B_HUMAN (1-724): 0: 1086: 100.00		ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37
+	Hs
		438117 HS90B_HUMAN (1-724): 0: 1086: 100.00		ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13
+	Hs
		438529 HS90B_HUMAN (1-724): 0: 1086: 100.00		Q9H4D1_HUMAN (9-155): 2.04e-30: 116: 25.68
+	Hs
		431704 HS90A_HUMAN (1-724): 0: 1072: 85.25		RIPK4_HUMAN (9-155): 1.21e-30: 117: 25.68
+	Hs
		432263 HS90A_HUMAN (1-724): 0: 1072: 85.25		Q9H4D1_HUMAN (9-155): 2.04e-30: 116: 25.68
+	Hs
		431682 HS90A_HUMAN (1-724): 0: 1072: 85.25		DAPK1_HUMAN (49-155): 4.06e-14: 70.4: 22.02
+	Hs
		276132 HS90A_HUMAN (1-724): 0: 1072: 85.25		PSD10_HUMAN (1-85): 4.57e-12: 63.1: 23.86
+	Hs
		538174 ENPL_HUMAN (3-693): 0: 917: 46.44		RIPK4_HUMAN (9-155): 1.21e-30: 117: 25.68
+	Hs
		538399 ENPL_HUMAN (3-693): 0: 917: 46.44		Q9H4D1_HUMAN (9-155): 2.04e-30: 116: 25.68